头发花白的杰克·科沃基恩（阿尔·帕西诺 Al Pacino 饰）是美国密西根州一名备受争议的医生，在几十年的职业生涯中，他亲眼见过无数人为病痛所折磨，却求生不得，求死不能。杰克坚信医生的职责不仅是要尽最大努力医治病患，更要设身处地为病人着想，满足他们的需求，包括他们对死的渴望。因此，杰克尝试帮对生活失去希望的病人施行安乐死。但是他的做法遭到了普罗大众的一致反对，人们斥责他剥夺病患的生命，更送他“死亡医生”的绰号。在这一过程中，只有姐姐玛格（Brenda Vaccaro 饰）和少数几个朋友默默支持着杰克的工作。 面对巨大的压力，杰克从未表现出退缩，他深知病患的痛苦，因此为了帮助他们解脱即时身陷囹圄也在所不惜……Dr. Jack Kevorkian (1928 - 2011 ) in the 1990s, when he defies Michigan law assisting the suicide of terminally-ill persons. Support comes from his sister, a lab tech, the Hemlock Society president, and a lawyer. The child of survivors of the Armenian genocide interviews applicants: his sister video tapes them. He assembles a device allowing a person to initiate a three-chemical intravenous drip. The local D.A., the governor, and the Legislature respond. In court scenes, Kevorkian is sometimes antic. He's single-minded about giving dying individuals the right to determine how their lives will end. He wants the Supreme Court to rule. He picks a fight he can't win: is it hubris or heroism?
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