一个是乐观乡下青年──徐荣源，一个则是古怪天才宅女──姜淑媛，上大学後，荣源藉各种学术研讨为由，让钻研在图书馆与实验室的淑媛接受他的友谊…当淑媛惊觉两人似乎已成男女朋友时，阿源早已成她生活中不可缺的元素… 鸡婆的内科医生与决心将生命奉献给真理的科学家，展开一连串谁也料想不到的「生命旅程」…Despite being poor, Jung-Yuen is a happy teenager who gets on well with his family. During high school, he develops a crush on Shu-Yuen, a girl from his neighboring village, who is extremely smart, but reclusive with an odd personality. After they both begin university, Jung-Yuen, a medicine major, comes up with every excuse he can think of to get Shu-Yuen's attention, who locks herself away from the world in the library and her laboratory. After a lot of effort, Jung-Yuen finally succeeds in winning her heart. Mysterious equation is an uncanny love story about an optimistic doctor and a scientist who was ready to dedicate the rest of her life to science.
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