天启年间,辽东关外怪病肆虐,人心惶惶,锦衣卫褚思镜(黄轩 饰)只身北上探查,不料却卷入当地军民斗争,在终日笼罩辽东的迷雾之后,无数诡谲阴谋也正潜滋暗长,无形的触手正伺机而动……The story is set during the late Ming Dynasty when a mysterious epidemic breaks out. It follows the thrilling journey of Chu Sijing, a member of the secret service, as he navigates a life-or-death crisis on a deserted island.