2012年,人类被不知名病毒感染,纽约成为一座空城。Robert Neville(Will Smith 饰)是为军方服务的科学家,也是对病毒有免疫力的幸存者。白天,他带着狗Sam在街道上寻找食物,用广播寻找幸存者,在实验室里研究治愈病毒的方法;晚上,他只能躲在屋子里,因为那些感染病毒而没有死亡的人们,成为了“夜魔”只能夜晚出来活动,丧失理智,会攻击所有的人。   某天,Sam也感染病毒死去,Robert Neville陷入了前所未有的孤独。当他准备和“夜魔”们同归于尽的时候,另外一个幸存者Anna(Alice Braga 饰)救了他。Anna相信山上的隔离区还有幸存者,但是固执的Robert Neville却坚持守在纽约。   又一个晚上,“夜魔”攻击Robert Neville的住所,此时他的研究已经获得成功,但是只有坚持到天亮,人类才能得以延存。Robert Neville is a scientist who was unable to stop the spread of the terrible virus that was incurable and man-made. Immune, Neville is now the last human survivor in what is left of New York City and perhaps the world. For three years, Neville has faithfully sent out daily radio messages, desperate to find any other survivors who might be out there. But he is not alone. Mutant victims of the plague -- The Infected -- lurk in the shadows... watching Neville's every move... waiting for him to make a fatal mistake. Perhaps mankind's last, best hope, Neville is driven by only one remaining mission: to find a way to reverse the effects of the virus using his own immune blood. But he knows he is outnumbered... and quickly running out of time.
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